Tumor-associated fibroblast-conditioned medium induces CDDP resistance in HNSCC cells
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چکیده
منابع مشابه
Tumor-associated fibroblast-conditioned medium induces CDDP resistance in HNSCC cells
OBJECTIVE EMT (epithelial to mesenchymal transition) contributes to tumor progression and metastasis. We aimed to investigate the effects of EMT on CDDP resistance in HNSCC (head and neck squamous cell carcinoma)-cells. METHODS EMT was induced using conditioned medium from a tumor cell/fibroblast co-culture. HNSCC cells were alternatively treated with TGF-β1. The response to CDDP was evaluate...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.6210